Which sandwich features mayo, lettuce, tomato, and beef?

The sandwich that features mayo, lettuce, tomato, and beef is the Big John. This sandwich is designed to showcase the flavor of the roast beef, complemented by the freshness of lettuce and tomato, as well as the creamy texture of mayonnaise. The combination of these ingredients makes it a classic choice for those who enjoy a meaty sandwich with classic condiments.

In contrast, other options like the Peppe, Turkey Tom, and The Veggie do not contain the same combination of ingredients. The Peppe focuses more on the flavor profile of salami and capicola, featuring other toppings. The Turkey Tom is centered around turkey and does not include beef, while The Veggie emphasizes vegetables and does not have any meat at all. This distinction clearly reinforces why the Big John is the accurate answer to the question.